Endocrine Abstracts

Exposure to supraphysiologic doses of exogenous glucocorticoids is associated with gastrointestinal (GI) complications such as peptic ulcer disease, gastrointestinal hemorrhage, duodenal ulcer, and colonic diverticular perforation (DP). Patients receiving high dose glucocorticoids, for rheumatological or autoimmune disease are at increased risk for lower gastrointestinal tract abscesses and perforation. However, little is known about GI complications in endogenous hypercortiso...

Introduction: Adrenocortical carcinoma (ACC) is a rare tumor with an aggressive prognosis of 1–2 people per million per year. They are functional tumors which mostly occur with virilization and/or Cushing syndrome. Metastatic ACC has a dismal prognosis and the most common sites of metastases are the lung, liver, lymph nodes and bones. Herein, we present metastatic ACC patient without Cushing clinic at the time of diagnosis.Case presentation: A 48-ye...

Introduction: Although the radiographic and histological features are the same as benign pheochromocytomas, malignant and metastatic pheochromocytoma is differentiated by invasion of the surrounding tissues and organ metastasis. Here, we present a young patient with a diagnosis of metastatic pheochromocytoma presenting with hypertension attacks, headache and flushing.Case presentation: A 22-year-old woman with a history of hypertension who had been suffe...

Introduction: Ten per cent of pheochromocytomas are malignant. Malign pheochromocytoma could cause metastasis, relapse and local invasion. The most common sites of metastasis for pheochromocytoma or extra-adrenal paraganglioma are lymph nodes, bones, lungs, and liver. Here, we present a case who had pheochromocytoma relapse and unusual peritoneal metastasis after 12 years of left adrenalectomy.Case presentation: A 38 year-old woman, who had left adrenale...

Introduction: Adrenocorticalcarcinoma (ACC) is a rare malignancy with an aggressive prognosis, an incidance of 1–2 cases/million/year. It is the cause of 0.2% of all cancer deaths. It is seen in the 4th and 5th decades in adults and mostly unilateral and sporadic. Herein, we present a case of sarcomatoid type ACC which is symptomatic with mass compression and hypertansive attacks.Case presentation: A-52-year-old male was referred to our endocrinolog...

Background: William-Beuren region duplication syndrome (WBDS) is a rare multisystem disease caused by the gain on chromosome 7q and transmitted autosomal dominant, with approximately a population frequency of 1 in 13,000-20,000. The age of diagnosis is variable, but generally, it is diagnosed during childhood. It include endocrine (growth hormone deficiency) and non-endocrine (facial dysmorphology, cardiovascular problems, gastrointestinal and genitourinary problems, neurologi...